Keira Knightley Pretty Sure She Doesn't Explode In 'Jack Ryan'

Actress describes Chris Pine-starring film as a 'good old-fashioned Hollywood thriller' — and promises she won't be in 'Fifty Shades of Grey.'
By Amy Wilkinson, with reporting by Josh Horowitz

Keira Knightley
Photo: MTV News

Source: http://www.mtv.com/news/articles/1698376/keira-knightley-jack-ryan-movie.jhtml

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Obama?s claim of the ?largest? discretionary cuts ?in history? (Washington Post)

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This Is Now the Coolest Microwave of All

Sure, this other microwave is "the most beautiful," and it certainly is "classy," "modern," and maybe even "timeless." But this microwave is a god damn dome. And because it's a dome, it wins it all. It wins microwaves. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/RE991tDwuQk/this-is-now-the-coolest-microwave-of-all

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Police: Indiana men had sex before fatal fight

This photo provided by The Howard County, Ind., Sheriff's Department shows Walter Logan. Logan was being held Monday, Dec. 4, 2012, on a preliminary murder charge in connection with the death of Alex Shipp whose badly decomposed body was found in an unplugged basement freezer of the Kokomo, Ind., home Logan was living in. Shipp's mother, who told police she hadn't heard from him in nearly a month, had reported him missing. (AP Photo/Howard County Sheriff's Department)

This photo provided by The Howard County, Ind., Sheriff's Department shows Walter Logan. Logan was being held Monday, Dec. 4, 2012, on a preliminary murder charge in connection with the death of Alex Shipp whose badly decomposed body was found in an unplugged basement freezer of the Kokomo, Ind., home Logan was living in. Shipp's mother, who told police she hadn't heard from him in nearly a month, had reported him missing. (AP Photo/Howard County Sheriff's Department)

INDIANAPOLIS (AP) ? Indiana authorities investigating the death of a homeless man whose decomposing body was found in a freezer say he had been drinking, taking drugs and having sex with another man now accused in his death.

The body of 29-year-old Alex Shipp was found Sunday in the basement of a home in Kokomo, about 50 miles north of Indianapolis. The resident, Walter Logan, 52, was being held without bond on a preliminary charge of murder Tuesday in the Howard County Jail.

Logan was scheduled for an initial court appearance Wednesday. He did not have an attorney.

According to a probable cause affidavit, Logan told police that he and Shipp developed a sexual relationship after meeting about two years ago.

He said he and Shipp had sex one night about four weeks before Shipp's body was found. He said the two had been drinking and taking drugs and that Shipp became belligerent and wanted to fight. Logan said he bound Shipp's hands and feet and placed tape over his nose and mouth and fell asleep.

He told police that when he awoke, he thought Shipp was dead but removed the tape and went back to sleep. When he awoke again, he said, he was certain Shipp was dead, but he waited about six hours before hauling his body to the basement.

Logan told police he removed the shelving from the freezer and stuffed Shipp's body inside the freezer, which was not plugged in, the affidavit states.

Worried that she hadn't heard from him since early November, Shipp's mother reported him missing Saturday. She had posted flyers that produced a tip that Logan and Shipp had been seen together at Logan's home. Police went to question him.

Logan told police he'd been expecting them, the court documents say. Investigators noticed a strong stench and asked Logan if Shipp was there. He led them to the basement freezer, which had been laid flat on the floor with a concrete block holding the door shut.

Investigators don't know whether Logan had intended to kill Shipp, Detective Michael Banush said Tuesday.

"We don't always get those answers," Banush said. But "it's just common sense if you duct tape someone's mouth and nose and then go to sleep" that they're likely to die.

Logan told police he tried to kill himself by ingesting pills and wrote a suicide note, but he fell asleep before he could finish it.

Logan served about three years in prison on a drug-dealing conviction, according to Indiana Department of Correction records.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-04-US-Freezer-Body/id-4ca3cc8973104e78b81a26c0609d1f07

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Mars rover Curiosity: No surprise in 1st soil test

LOS ANGELES (AP) ? Results are in from the first test of Martian soil by the rover Curiosity: So far, there is no definitive evidence that the red planet has the chemical ingredients to support life.

Scientists said Monday a scoop of sandy soil analyzed by the rover's chemistry lab contained water and a mix of chemicals, but not the complex carbon-based compounds considered necessary for microbial life.

The latest findings reported at a meeting of the American Geophysical Union meeting in San Francisco came from an instrument aboard the six-wheel rover that baked the soil and analyzed the gases released.

Curiosity landed in Gale Crater near the Martian equator in August on a two-year mission to study whether the environment on Mars could have been favorable for life.

The dirt at Curiosity's landing site appeared similar to that found in regions visited by other Mars spacecraft, scientists said. It contained water, sulfur and possibly perchlorate, a compound made up of oxygen and chlorine. NASA's Phoenix lander, which touched down near the Martian arctic, previously found perchlorate in the soil.

The rover did find a simple carbon compound, but scientists have yet to determine whether it's native to the red planet, or came from elsewhere.

Scientists think the best chance of finding complex carbon is at Mount Sharp, a 3-mile-high mountain rising from the crater floor. Curiosity won't trek there until early next year.

A comment two weeks ago by the mission's chief scientist led to speculation that Curiosity had made a major discovery that would be announced Monday. But NASA last week said that wasn't the case.

The rover is the most sophisticated spacecraft sent to Mars. The rover Opportunity has been exploring craters in Mars' southern hemisphere since 2004. Opportunity's twin, Spirit, fell silent in 2010 after getting stuck in a sand trap.

___

Online:

NASA: http://mars.jpl.nasa.gov/msl/

Source: http://news.yahoo.com/mars-rover-curiosity-no-surprise-1st-soil-test-175738039.html

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Exercise And The Limitations Of Observational Studies ? CardioBrief

Last week I wrote twice about exercise.?Strictly speaking, both stories were complete lies.

The first story was about?a?study published in the?Lancet?which analyzed data from more than 10,000 patients at 2 VA Medical Centers and found that patients with high fitness levels were less likely to die than patients with low fitness levels. The pattern held true whether patients were taking statins or not taking statins. The researchers concluded:

?Statin treatment and increased fitness are independently associated with low mortality among dyslipidaemic individuals. The combination of statin treatment and increased fitness resulted in substantially lower mortality risk than either alone, reinforcing the importance of physical activity for individuals with dyslipidaemia.?

Look carefully at that. The?association of fitness and low mortality leads to the recommendation about ?the importance of physical activity.? An?accompanying editorial?went further, recommending that??prescription of physical activity should be placed on a par with drug prescription.? Widespread media coverage of the study followed suit, with nearly all reports emphasizing the positive effects of exercise.

So what?s wrong here? It almost seems churlish to insist on the point, but of course the study (like all other observational studies) didn?t? couldn?t? actually say anything about the real effect of exercise on health. It seems reasonable to assume that more exercise leads to increased fitness leads to improved health. That?s what we all probably think and believe. It?s common wisdom. But it?s not entirely unreasonable to suppose that healthy people are much more likely to exercise, in effect reversing the cause and effect. And of course there may be other confounding factors that cloud the simple equation of exercise and health.

There?s more: even if you could prove that more exercise leads to better health that wouldn?t lead to an automatic conclusion that doctors should recommend exercise as much as drugs. First you would need to prove that an exercise prescription is just as effective as a drug prescription. It?s hard enough to get people to take inexpensive, life-saving drugs once a day. Is there any reason to think we can get any kind of effective level of compliance with an exercise prescription?

The other exercise story from last week had a much different conclusion. Editorialists in Heart?concluded that although most exercise is good for you,?too much?exercise can actually be harmful.?They may well be right, but there?s never been? and there almost certainly never will be? a good, properly designed randomized trial that could prove this theory. It?s entirely possible (in fact, almost certain) that people attracted to extreme endurance sports are different in many ways from the rest of us, and it?s quite plausible that some of those differences may have significant effects on health. Confounded again.

The last thing I want to do is trash exercise. I?m a big supporter of it. But these standards shouldn?t be compromised. So what is the proper way to report this kind of study? Here?s a brief, completely responsible version of the story (written by Kelly Young for?Physician?s First Watch):

Exercise Plus Statin Therapy Associated with Reduced Mortality

Physical activity and statin use, both independently and combined, are associated with reduced mortality risk among patients with elevated cholesterol, according to a?Lancet?study.

Researchers prospectively collected data on roughly 10,000 veterans (mostly male) with dyslipidemia who underwent exercise tolerance tests. Over a median follow-up of 10 years, statin users had a mortality risk of 18.5%, while nonusers had a mortality risk of 27.7%. The mortality risk was reduced among the fittest participants, both among nonusers and users of statins.

The authors conclude: ?Improved fitness is an attractive adjunct treatment to statins or an alternative when statins cannot be prescribed. The low exercise capacity (roughly 7 MET) associated with the aforementioned health benefits is clinically significant and reinforces the importance of physical activity for individuals with dyslipidemia.?

This works well for a professional readership, but it?s hard to imagine how this could be reported to consumers in a responsible way. Every story about an observational study would need to turn into a lesson in the limits of such studies, though this would no doubt please Gary Schwitzer and his great reviewers at HealthNewsReview.

I discussed this issue with a distinguished cardiologist known for his scientific rigor (in fact, he pointed me to the?First Watch story as a model for coverage of the Lancet study). He agreed that the?Lancet study supported ?the idea that fitness is a good thing for longevity? and agreed that ?it seems reasonable to encourage fitness.? But, he observed, ?prescribing exercise is not without direct and indirect costs for doctors (who use the short time with patients to focus on that issue rather than something else) and patients (who may then allocate time for exercise, which costs them time and maybe dollars). The question in the end is how confident can you be that it matters for life expectancy.?

I don?t have a solution to this problem, just a few observations. A reasonable recommendation to people to exercise more need not require the same level and depth of evidence as a recommendation for a drug or a device. Although it?s certainly true that exercise has its own risks and dangers, these are risks that most people can intuitively understand. The same can not be said for drugs and devices.

I?m also not convinced that prolonging life is the best reason to exercise. Fitness may be its own best reward. By definition, fit people are well suited to their environment. That strikes me as a reasonable goal. Is there anyone who would argue that being unfit is desireable?

Source: http://cardiobrief.org/2012/12/03/exercise-and-the-limitations-of-observational-studies/

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